The pilot project leading to the pilot data for the Czech Brain Aging Study (CBAS) was established in 2005 as a longitudinal follow-up of subjects at risk of Alzheimer disease (AD) dementia. A major step forward occurred in 2011 after receiving a substantial funding from the European Union Regional Development fund and the Czech Ministry of Health. This funding enabled to establish the International Clinical Research Center (ICRC) in Brno and also enabled to synchronize our efforts in clinical and translational research between the ICRC and the Cognitive Center at Department of Neurology of the Motol University Hospital in Prague.
CBAS now recruits a large numbers of participants across the two sites and is the only longitudinal study of its kind in the Czech Republic. It is also about to become the largest study to study risk factors for AD in Central and Eastern Europe.
Participants undergo annual follow-up with clinical evaluations, multimodality brain MRI, comprehensive standardized neuropsychological testing including “challenging” memory tests aimed to detect early cognitive decline and laboratory examination. The APOE, TOMM40 and BDNF genotyping is done at baseline. In a subset of participants, CSF and/or amyloid PET is performed. The majority of participants also undergo a unique translational, experimental neuropsychological protocol that has been inspired by animal research. This protocol consists of various tasks aiming to detect early cognitive and clinical impairment in AD spectrum. The strong translational aspect of this approach, which includes the use of the human analogue of the Morris Water Maze, is aimed at the identification of individuals at preclinical and prodromal stages of AD. Biological sample bank (DNA, CSF and plasma) matched with the CBAS clinical data is also a part of CBAS.
From a biological point of view, one aim of the CBAS is to biochemically characterize the subjects affected by AD Dementia and related memory disorders. The search for new biomarkers has expanded in the last years in the attempt to characterize the disease stage and/or predict the disease course. Our view is that single measurement of biomarkers in plasma, serum or cerebrospinal fluid has been shown to be not sufficient per se and must be corroborated with combined biomarker measurements. At this regard, we are working on expanding the number of measurable biomarkers by including proteins related to the neuronal activity in the CNS, such as neurotrophic factors, enzymes regulating protein expression, and proteins related to neuronal/synaptic function, such as neurofilament light protein, neurogranin and contactin-2.
Collect biological samples for genetic and biochemical analysis (CSF, serum, DNA)
Assess the participants using neuropsychological and cognitive evaluations using our standardized clinical and experimental protocols
Perform brain MRI for the longitudinal study of brain atrophy, white matter changes and changes in the brain diffusivity. In subset, resting state fMRI is performed.
Mentor PhD students and postdocs; encourage internships and personnel exchange (experimental neuropsychology, spatial navigation, imaging)
Provide clinical and cognitive assessments for both, clinical research and diagnostic purpose
Conduct non-pharmacological interventions such as Mindfulness Based Stress Reduction Therapy
Our objective is to describe the changes in the cognition over time, brain structure (using MRI), metabolism (cerebro-spinal fluid analysis) and molecular imaging (amyloid PET). Our focus is on those with subjective cognitive decline (SCD), mild cognitive impairment (MCI) and healthy elderly participants - a CBAS cohort. We are also interested in participants with various neurodegenerative dementia syndromes and vascular cognitive impairment (VCI) - a CBAS plus cohort. Our spectrum of diagnoses includes Alzheimer disease, frontotemporal lobar degeneration, dementia with Lewy bodies, Parkinson disease, progressive aphasias, progressive supranuclear palsy, corticobasal degeneration, vascular cognitive impairment and others.
The information on participants is entered into CBAS database that contains clinical, laboratory, genetic, socioeconomic and life style variables.
V Úvalu 84, 150 06, Praha 5 - Motol, Czech Republic
Jsme ve 2. patře, výtah D
Pekařská 53, 656 91 Brno, Czech Republic